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  • February 13, 2013

    Ground breaking insulin pill nearing market

    By Abigail Klein Leichman, Israel 21C

    For 100 years, scientists searched for a way to deliver insulin orally instead of by injection. Now an Israeli team claims it’s found the solution. Phase 2 clinical trials are coming.

    Swallowing a pill is much more palatable for diabetics than getting an injection. Photo via Shutterstock

    Swallowing a pill is much more palatable for diabetics than getting an injection. Photo via Shutterstock* 

    Jerusalem’s Oramed Pharmaceuticals is one step closer to putting a groundbreaking oral insulin capsule on the market for people with Type 2 diabetes. The company is about to begin Phase 2 clinical trials on 147 people at about a dozen medical centers in the United States.


    CEO Nadav Kidron tells ISRAEL21c that the company’s flagship product could revolutionize the treatment of diabetes, which now affects more than 371 million people worldwide and is the seventh leading cause of death in the United States. Most cases are Type 2, where the body does not use the hormone insulin effectively to metabolize sugars.

    The current method of self-injecting insulin is unpleasant and also carries the constant risk of infection. A capsule taken by mouth would be more convenient and also more natural, as it would mimic insulin’s normal route in the body. But until now nobody had found a way to orally deliver large-molecule polypeptides such as insulin and vaccines.

    Israel is a major center for diabetes research, and in fact the technology underlying Oramed is based on 25 years of research at Hadassah University Medical Center in Jerusalem by scientists including Kidron’s mother, Dr. Miriam Kidron.

    “After the breakthrough, we sat and talked about how it could help millions, but to do that you need to establish a company and get it financed,” Kidron relates. “I’m a lawyer with an MBA, so I started the company and raised the money nearly eight years ago.” The elder Kidron is chief medical and technology officer of the publicly owned Oramed, and Hadassah is a stakeholder.

    “When they initiated this project almost 30 years ago at Hadassah, trying to get insulin delivered orally looked almost impossible,” says Kidron. “Today it’s just a matter of time till it’s on the market.”

    Insulin capsule can slow the progression of diabetes

    Kidron explains that Oramed’s management decided to focus solely on insulin not only because of the founding scientists’ expertise in diabetes research, but also because insulin levels are quite easy to measure in the blood.

    And from a business standpoint, diabetes represents a giant market. Some $471 billion was spent worldwide last year to treat diabetes, and the International Diabetes Foundation estimates that by 2030, some 552 million people in the world will be diagnosed with the disease.

    Most importantly, says Kidron, Oramed’s insulin capsule could slow the progression of Type 2 diabetes, which has three classic phases.

    The first phase can be addressed through diet and exercise, while the next phase requires oral medications that boost the body’s own insulin production. In the third phase, when the insulin-producing pancreas cannot continue producing the hormone, a patient becomes insulin-dependent.

    “We wanted to do more than just replace injections — we wanted to provide an alternative oral medication as an earlier treatment that can extend the second phase and prevent patients from becoming insulin dependent,” says Kidron. “That’s the revolution.”

    Nadav Kidron, CEO of Oramed Pharmaceuticals
    Nadav Kidron, CEO of Oramed Pharmaceuticals

    By offering a better solution in the second phase of the disease, Oramed could assure that people with Type 2 diabetes avoid further complications of the disease, while benefiting from a less painful, more convenient and more affordable treatment.

    Other diabetes meds in the pipeline

    Because Type 2 diabetes often results from excess body weight, Oramed is also developing an oral capsule containing the hormone exenatide, which helps balance blood sugar levels and controls appetite. Exenatide can be given by injection but it tends to make people nauseous. The oral preparation would reduce that side effect and open it up to a much larger market.

    “This is a very potent drug in the world of diabetes. We are now doing trials at Hadassah, and probably toward the end of the first quarter of 2013 we should have results,” says Kidron. “If it’s successful, we will then file for FDA approval.”

    Oramed has a third product in the pipeline that combines oral insulin and oral exenatide. Preliminary results of this therapy were presented at the meeting of the American Diabetes Association last June, demonstrating a greater positive effect when the two products were given in tandem.

    “We saw that one plus one equals three when people take these together,” says Kidron, “and giving them together is better than giving them separately. So it’s another breakthrough not just in delivery but in combining these products.” Human trials have yet to begin but results in animal models are promising.

    Though the company employs just 11 people, Oramed is backed by a scientific advisory board that includes top diabetes researchers. It includes, among others, Nobel Prize laureate Dr. Avram Hershko; Dr. Michael Berelowitz, former senior vice president of Pfizer; Gerald Ostrov, former CEO of Bausch & Lomb and former senior executive of Johnson & Johnson; and Prof. Derek LeRoith, chief of endocrinology, diabetes and bone disease at the Mount Sinai School of Medicine in New York.

  • Posted by Ted Belman @ 8:39 pm | 6 Comments »

    6 Comments to Ground breaking insulin pill nearing market

    1. NormanF says:

      Israel Saves Lives!

      No doubt Israel haters will accuse Israel of Insulin-Washing in the future.

    2. Eric R. says:

      @ NormanF:

      Norman,

      Muslims blame everything on Jews the way the leftist media blames everything on global warming.

    3. Laura says:

      Perhaps any boycotters who have diabetes or anyone in their families who have it, will stand on principle and not use this product.

      And meanwhile the world rages at Israel and regrets her creation, but not of her numerous enemies who’s only contribution to humanity is global mass murder in the name of islam. A very insane world we live in.

    4. Honey Bee says:

      As a very young man my father was an early user of insulin,at the University of Chigago,he would be so glad to this news. What a blessing!

    5. BethesdaDog says:

      @ Laura:

      Yes, just what I was thinking. Stand on principle, and boycott this, and your laptops and thumb drives (so essential to the modern, on-the-go jihadi terrorist) and whatever else has some Israeli or Jewish connection. After all, Polio is so much fun!

    6. steven l says:

      @ Laura:
      It is all about jealousy!

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